Tumor Cell Secretomes in Response to Anti- and Pro-Tumorigenic Agents

Tumor cells regulate their progression not only by the factors within cell bodies but also secretome they produce and secrete. While significantly alters fate of tumor themselves, growth surrounding including both companion cancer non-cancer cells. consists varying molecules that have been reported mostly tumor-promotive. Furthermore, pro-tumor capability is enhanced application chemotherapeutic agents. However, multiple lines emerging evidence suggest can be tumor-suppressive in response to paracrine endocrine signaling. This review introduces tumor-promotive secretomes, focusing on multi-tasking proteins intracellular extracellular domains. We describe tumorigenic signaling governs nature discuss possibility inducing proteomes as a novel option for treatment. evaluated counterintuitive procedure generate from unique type tumor-modifying cells, which are named “induced tumor-suppressing cells” (iTSCs).